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2 edition of Depsipeptides as [beta]-lactamase substrates. found in the catalog.

Depsipeptides as [beta]-lactamase substrates.

Chandrika Poorna Govardhan

Depsipeptides as [beta]-lactamase substrates.

by Chandrika Poorna Govardhan

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Published by U.M.I. in Ann Arbor, Mich .
Written in English


ID Numbers
Open LibraryOL13838788M

Send Orders of Reprints at [email protected] 34 The Open Microbiology Journal, , 7, (S u p p l 1 - M 3) Open Access Microbial Efflux Systems and Inhibitors: Approaches to Drug Discovery and the Challenge of Clinical Implementation Christina Kourtesi1,2, Anthony R. Ball3, Ying-Ying Huang4,5, Sanjay M. Jachak6, D. Mariano A. Vera7, Proma Khondkar8 Simon . Sugahara, K., Nadanaka, S., Takeda, K., & Kojima, T. (). Structural analysis of unsaturated hexasaccharides isolated from shark cartilage chondroitin sulfate D that are substrates for the exolytic action of chondroitin ABC lyase. European Journal of Biochemistry, , – PubMed CrossRef PubMedCentral Google ScholarAuthor: Saleena Mathew, Maya Raman, Manjusha Kalarikkathara Parameswaran, Dhanya Pulikkottil Rajan.

No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law. The book includes information on the different classes of marine microorganisms and the different bioactives that can be extracted from bacteria, fungi and microalgae. Divided into 7 chapters, the book covers bioactive marine natural products, such as marine microbes, seaweeds, and marine sponges as potential sources of drug discovery, and.

Structural studies and anticancer activity of a novel class of beta-peptides. D. T. Thielemann, A. T. Wagner, Y. Lan, P Efficient Synthesis of Lactate-containing Depsipeptides by the Mitsunobu Reaction of Lactates. S. Bräse, Proline as an asymmetric organocatalyst; RSC book: Sustainable Catalysis, Ed. M. North, , RSC Green.   Virulence factors comprise a large spectrum of various enzymes and exotoxins that enable the evasion of the immune system and tissue adhesion or cause damages to the host cell. 39 –41 Proteases, lipases, and nucleases, for example, take part in the tissue invasion, whereas leukocidins enable the evasion of the immune response. 39 Sepsis, on Cited by:


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Depsipeptides as [beta]-lactamase substrates by Chandrika Poorna Govardhan Download PDF EPUB FB2

The Cyclization of Peptides and Depsipeptides Article Literature Review in Journal of Peptide Science 9(8) August with Reads How we measure 'reads'Author: John S. Davies. On the basis of their striking structural similarity to the marine depsipeptides jaspamides, the chondramides have been assumed to incorporate a (R)-β.

A process for removing β-hydroxy groups from β-hydroxy-containing compounds is disclosed. The process involves the use of a retro-aldol-promoting reagent selected from the group consisting of trimethylamine-N-oxide, triethylamine-N-oxide, trimethylamine-N-oxide hydrate, and trimethylamine-hydrate and requires dissolution of the substrate in an aprotic solvent and Cited by: 4.

C.R. Wilson, in Comprehensive Toxicology, Amatoxins. Amatoxins, present in Amanita, Lepiota, and Galerna species of mushrooms, are RNA II polymerase inhibitors and cause nausea, vomiting, and severe gastroenteritis after ingestion of the mushroom (Jan et al.

).In acute exposures to Amanita phalloides, amatoxins are usually detectable in the. The jaspamide/chondramide family of depsipeptides are mixed PKS/NRPS natural products isolated from marine sponges and a terrestrial myxobacterium that potently affect the function of the actin cytoskeleton.

As a first step to improve production in heterologous host cells and permit genetic approaches to novel analogs, we have cloned and characterized the chondramide Cited by: Microbial Efflux Systems and Inhibitors: Approaches to Drug Discovery and the Challenge of Clinical Implementation Christina Kourtesi, 1, 2 Anthony R Ball, 3 Ying-Ying Huang, 4, 5 Sanjay M Jachak, 6 D Mariano A Vera, 7 Proma Khondkar, 8 Simon Gibbons, 8 Michael R Hamblin, 4, 5, 9 and George P Tegos *, 1, 4, 5, 10Cited by:   Quorum sensing (QS) is a signaling mechanism that is quite common in bacteria and involves the exchange of small chemicals between bacteria.

It was first identified in the marine bacterium Vibrio fischeri. 1 – 3 QS describes the ability of an organism to adapt the activity of its gene expression machinery to the population density in the Cited by: Abiogenesis, or informally the origin of life, is the natural process by which life has arisen from non-living matter, such as simple organic compounds.

While the details of this process are still unknown, the prevailing scientific hypothesis is that the transition from non-living to living entities was not a single event, but an evolutionary process of increasing complexity that involved. Christopher Chang, in Personalized Epigenetics, Butyrates, Benzamides, and Cyclic Peptides.

Earlier compounds with HDAC activity include butyrates such as phenylbutyrate, benzamides, and cyclic peptides such as depsipeptides and apicidin [39].The HDAC inhibitors phenylbutyrate and trichostatin A (TSA) have been studied in a rat model of RA.

The. Abstract. Amyloid-β (Aβ) has been proposed as a biomarker and a drug target for the therapy of Alzheimer’s disease (AD). The neurotoxic entity and relevance of each conformational form of Aβ to AD pathology is still under debate; Aβ oligomers are considered the major killer form of the peptide whereas monomers have been proposed to be involved in Cited by: 3.

We are pleased to offer new custom prototype fluorogenic substrates targeting the SARS-CoV and SARS-CoV-2 Main Protease (M pro).The main protease (M pro­), also called endopeptidase C30 or 3C-like proteinase (3CL pro), controls viral replication activities and is a prime therapeutical substrates and inhibitors of SARS-CoV-2 M pro, are currently of.

β- and γ-Di- and Tripeptides as Potential Substrates for the Oligopeptide Transporter hPepT1 β-Depsipeptides—the effect of a missing and a weakened hydrogen bond on the stability of the β-peptidic helixElectronic supplementary information (ESI) available: NMR and NOE data. Learn more about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November (both PDF and HTML) across all institutions and individuals.

These metrics are regularly updated to reflect usage leading up to the last few days. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received Cited by: An NMR study of keto-enol tautomerism in β[beta]-dicarbonyl compounds Catalytic recruitment by phosphonyl derivatives as inactivators of acetylcholinesterase and substrates for imidazole-catalyzed -deuterium isotope effects.

Journal of the American Chemical Society Peptides are important bioactive natural products which are present in many marine species. These marine peptides have high potential nutraceutical and medicinal values because of their broad spectra of bioactivities.

Their antimicrobial, antiviral, antitumor, antioxidative, cardioprotective (antihypertensive, antiatherosclerotic and anticoagulant), immunomodulatory, Cited by: In addition to d-Ala-d-Ala, the formation of d-Ala-d-Ser dipeptides or d-Ala-d-Lac depsipeptides can also be catalyzed by Ddls.

The Poly-α-Glutamic Acid (αPGA) Synthetase RimK RimK is a member of the ATP-dependent carboxylate-amine/thiol ligase superfamily, which is reported to catalyze the modification of ribosomal protein S6 (RPS6) from Cited by: 1.

Journal of Immunology, ISSN02/, VolumeIssue 4, pp. - () Book chapter: Chiang, P.-C.; Bode, J. "N-Heterocyclic Carbenes as Organic Catalysts" N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools (Edition 2) [Ed: Silvia Diez-Gonzalez].

Kutznerides 2 and 8 of the cyclic hexadepsipeptide family of antifungal natural products from the soil actinomycete Kutzneria sp. contain two sets of chlorinated residues, a 6,7-dichlorohexahydropyrroloindole moiety derived from dichlorotryptophan and a 5-chloropiperazate moiety, as well as a methylcyclopropylglycine residue that may arise from isoleucine via a Cited by: The oceans of the world cover roughly 71% of the planet and have a median depth of >3, m and a mean depth of 3, m.

Of this vast expanse, less than 5% of the deep sea has been explored in any way and less than % of the deep sea floor has been sampled in detail [].What is often not realized is that, of the 36 animal phyla listed taxonomically, 34 are found in the.

You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them., Free ebooks since Brings together world experts and their research on the architecture, biochemical pathways, genetic organization, and gene regulation of Bacillus subtillis.

Offers tables and figures along with chapters that serve as very accessible references for essential facts. Reflects the recent and rapid advances in studying gram-positive bacteria and makes useful comparisons among diverse .Photolysis of caged peptides that have a photocleavable protecting group on side chain and main chain Photolysis of caged peptides that have a photocleavable protecting group on side chain and main chain Design and synthesis of beta-secretase inhibitors containing hydroxy-methylcarbonyl isostere as a transition state mimic.